Preclinical study by WIVR researchers finds adverse immune response to allogenic subretinal stem cell transplantation. (PDF) We generated retinal pigment epithelial cells from the skin of one strain of pig and successfully implanted them under the retina of unrelated pigs and found that this induced an immune response in the host, which is concerning for graft rejection. These findings suggest that immunologically matched cells will be important for retinal cell replacement.
iPSC-based RPE cell transplant study
July 3rd, 2015