In this month's CP Stem Cell Biology, we have a brand new protocol describing a method for the sectioning and immunohistochemistry of 3-D organoids (a miniature organ produced in vitro). You can check out the full paper here. In brief, this is a protocol for using iPSC-derived 3-D organoids to assess developmental processes that occur during the formation of the organoid.
Recent News
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May 16th, 2016
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November 6th, 2015
In March 2015, the WIVR participated in a Congressional Briefing on Usher Syndrome. During that briefing, Dr. Stone outlined the WIVR’s roadmap for the cure of this disease.
Speakers at this briefing included Mark & Bella Dunning, and Moira Shea (Usher Coalition), Congressman David Young (R-Iowa), and Dr. Edwin Stone. A video of this briefing is available on YouTube.
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October 26th, 2015
Today, researchers of the Wynn Institute for Vision Research announced the discovery of the gene responsible for the inherited macular disease known as North Carolina Macular Dystrophy (NCMD). This discovery was electronically published on the same date in the journal Ophthalmology (LINK). The project was a collaborative effort of 20 scientists, including Kent Small, M.D., a Los Angeles retina specialist and first author of the paper, who has studied NCMD for almost 30 years.
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October 26th, 2015
WIVR investigators have just reported the discovery of a new genetic cause of retinitis pigmentosa (LINK). The gene TRNT1 is responsible for adding the CCA nucleotides to the 3' of tRNAs, and is therefore essential for translation of messenger RNAs into proteins. Severe genotypes in TRNT1 have been previously shown to cause a serious syndromic disorder that includes sideroblastic anemia.
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July 3rd, 2015
Preclinical study by WIVR researchers finds adverse immune response to allogenic subretinal stem cell transplantation. (PDF) We generated retinal pigment epithelial cells from the skin of one strain of pig and successfully implanted them under the retina of unrelated pigs and found that this induced an immune response in the host, which is concerning for graft rejection. These findings suggest that immunologically matched cells will be important for retinal cell replacement.
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April 13th, 2015
The University of Iowa Stephen A. Wynn Institute for Vision Research announced today two large steps forward in the battle against blinding eye disease. Both are made possible by a major gift from California businessman, photographer, environmentalist and philanthropist Howard F. Ruby.
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December 5th, 2014
Scientists at the WIVR recently published a manuscript in the high impact journal, Progress in Retinal and Eye Research, titled "Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy." LINK This manuscript reviews new data showing vascular loss as a very early event in age-related macular degeneration, proposes a hypothesis for how genetic risk factors lead to AMD, and discusses the implications of this model on the development of new therapies.
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July 23rd, 2014
Here is Buddy's Drive for the Cure video that aired on the Big Ten Network earlier this month.
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April 8th, 2014
Lazier Partners Racing has chosen to bring awareness to the University of Iowa’s Stephen A Wynn Institute for Vision Research [Press release; Buddy's Drive for the Cure]. Buddy Lazier, the 1996 Indianapolis 500 winner and 2000 Verizon IndyCar Series champion, will drive the No. 91 University of Iowa Stephen A. Wynn Institute for Vision Research car in the 2014 Indianapolis 500.
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August 8th, 2013
IOWA CITY, IA — Stephen A Wynn has made a $25 million gift commitment to the University of Iowa to support the UI’s Institute for Vision Research (video of ceremony, announcement video). The gift, which was announced at today’s meeting of the State Board of Regents in Ames, will be used to accelerate progress toward cures for rare, inherited retinal diseases.