A team of IVR researchers have demonstrated the biocompatibility of scaffolds carrying human iPSC-derived retinal progenitor cells. These results were recently published in the journal Cell Transplantation (LINK). There are two major challenges to cell-based therapies. The first is the potential for immunologic rejection of the injected materials.
August 1st, 2022
Choroidal endothelial and macrophage gene expression in atrophic and neovascular macular degenerationJuly 10th, 2022
A team of IVR researchers investigated the transcriptional changes in the choroid that occur during macular degeneration. This study published in the journal Human Molecular Genetics (LINK).
June 1st, 2022
A team of IVR researchers characterized the safety and efficacy of a new treatment for early stage MAK-associated retinitis pigmentosa (RP). This research was recently published in the journal Gene Therapy (LINK).
May 1st, 2022
A team of IVR researchers investigated the impact of under- and over-expressing complement factor H (CFH) in choroidal endothelial cells. This research was published in The Journal of Pathology (LINK).
March 1st, 2022
IVR researchers investigated the relationship between mutation proportion and disease severity in MELAS. This research was published in Human Molecular Genetics (LINK).
December 9th, 2020
On Wednesday, December 16th Dr. Stone discussed the culture, research, and mission of the IVR. To view a recording of the event, click here.
November 3rd, 2020
A group of IVR researchers recently developed Spectacle, a framework for exploring single-cell RNA-Seq datasets. They used Spectacle to provide access to several human retinal and choroidal single-cell datasets to the research community. The Spectacle resource can be found at singlecell-eye.org. The full publication can be found here.
October 29th, 2020
IVR researchers recently published an article exploring the utility of patient-derived induced pluripotent stem cells (iPSCs) to model to validate and expand the catalog of disease-causing variations. Integrating iPSC-based modeling into the process of molecular diagnosis is expected to enable a major influx of variant discovery and expanded treatment of inherited retinal disease. The full publication can be found here.
September 23rd, 2020
A group of IVR researchers published an article, reporting a detailed protocol for differentiating iPSCs into choroidal endothelial cells. This protocol will be useful for developing in vitro models toward understanding the mechanisms of choroidal endothelia cell loss early in AMD. The full publication can be found here.
Development of a Gene Therapy Vector for the Treatment of RPGR-associated X-linked Retinitis PigmentosaMay 20th, 2019
IVR researchers recently published an article presenting the development and evaluation of a gene therapy vector for RPGR, the 3rd most common cause of all inherited retinal disease. This gene is a challenging therapeutic target, because gene therapy vectors containing wild-type RPGR sequence, which includes the highly repetitive low complexity region ORF15, are extremely unstable. They exhibit accumulations of genomic changes during the process of propagating the viral plasmid.